As a result, conventional antioxidants such as vitamin E, BHT, BHA etc. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. My Account Retinoids are widely regarded as being among the most powerful (if not the most powerful) and effective anti-aging active compounds available. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). These derivatives are metabolized to the active form by skin cells. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. are recommend to help protect the novel retinoid in the formula. Has anyone actually seen positive results with the granactive? This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Granactive Retinoid 5% in Squalane (High Strength, No to Low I… Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. The novel retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. Both samples were prepared to a working stock concentration of 0.1% wt. Retinol (>95%, Sigma‐Aldrich) was dissolved in DMI. The Power of Retinol Without the Irratation. Granactive Retinoid is compliant in most global regions, including China. Clinical results for Granactive Retinoid, Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide, customerservice@cosmeticsandtoiletries.com, Local irritation and sensitisation potential assay, Skin irritation potential vs. retinol palmitate, Toleration under environmental stresses vs. retinol palmitate. The novel retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. Search results for. Contact her at gmazur@timesshamrock.com , … There is a bit of skin pilling everyday but it’s minor, manageable, non-invasive and satisfying quite frankly. The Ordinary Granactive Retinoid 2% Emulsion Garden of Wisdom Granactive Retinoid 5% Serum Be Minimalist Granactive Retinoid 2% (Emulsion) BFFECT Granactive Retinoid Emulsion 2% + Gaba The Ordinary Granactive Retinoid 2% In Squalane The Ordinary Granactive Retinoid 5% In Squalane Pacifica Clean Shot Granactive Retinoid 5% In Seawater This Works My … The effectiveness of Granactive Retinoid at filling lines and wrinkles can be seen in Image 1. Levin explains that while retinoids and retinol do exactly the same thing, it typically takes longer to see results from retinols compared to retinoids. The low irritation profile of Granactive Retinoid versus retinol was demonstrated on a 24 hour occlusive patch test and can be seen in Image 2. Retinoic acid is a topically applied ingredient recognized for its anti-ageing benefits; however, it can be irritating to skin and is sold as a prescription medication. Note: When pregnant or breastfeeding, it is recommended to avoid any skincare products containing retinoids such as formulations with Granactive Retinoid or Retinol. The Ordinary’s extended portfolio of retinoids includes the following formulations: Granactive Retinoid 2% Emulsion (Moderate Strength, No Irritation) Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) Granactive Retinoid 5% in Squalane (High Strength, No to Low Irritation) Retinol 0.2% in Squalane (Low Strength, Moderate Irritation) Retinol 0.5% in Squalane (Moderate Strength, High … This offers easy formulation into O/W emulsions, W/O emulsions and other formula types. granactive retinoid. For anti-acne claims, the retinoid must be co-formulated with an approved anti-acne active as subject to regional legislation. The novel retinoid delivers high performance compared to retinol derivatives, but with a significantly lower irritation potential. Description This fast absorbing, oil-like serum contains a 2% concentration of an advanced retinoid active complex called Granactive Retinoid (Hydroxypinacolone Retinoate). Bakuchiol: International journal of cosmetic science 36 (3) DOI: 10.1111/ics.12117 Source: PubMed January 2014 The same process improves overall skin clarity, and appearance is enhanced for a healthier complexion. Good to know: the trade name of HPR is Granactive Retinoid. Retinoids are known to have positive effect on aged skin.1 The novel retinoid combats the appearance of fine lines and wrinkles for a younger appearance while increasing skin elasticity for firmer, smoother skin texture. The novel retinoid should be added to the oil phase of all emulsion types, with a clinical use level of 1-2%. It has been shown to offer results against multiple signs of aging without the common drawbacks often associated with retinol. When a product claims 2% Granactive Retinoid, it means 0.2% Hydroxypinacolone Retinoate (and 1.8% dimethyl isosorbide) on the ingredient list. Utilizing a high concentration of two next-gen retinoids (proven to be more effective than standard retinoids) this lightweight, milky-textured serum works hard to defeat the main signs of skin aging. I'm thinking of switching to their non granactive retinol line. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. 625SI.1 - January 15, 2014 3. Stimulating these age defying processes in the skin is critical for fighting and reversing signs of aging. Stimulating these age-defying processes in the skin is critical for fighting and reversing signs of aging. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. The manufacturer produces it as 10% active and 90% solvent called dimethyl isosorbide. Congrats on your results, it sounds amazing. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. A gentle, effective anti-aging serum. I chose it because it is listed as high strength, but with no to low irritation. The Granactive Retinoid 2% Emulsion is milky/creamy in … Granactive Retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. So when you see a percentage of granactive retinoid being quoted, be aware that you need to divide by 10 to get the actual concentration of HPR. HPR is a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid; Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. Assessment of Skin Irritation Potential of Granactive Retinoid and Retinol Palmitate in a Reconstructed Human Epidermal Model Report No. Sample preparation: Granactive Retinoid is 10% wt. Medica Labs uses scientifically proven ingredients to formulate advanced skin care products. You can’t go back in time, but Medica Labs will continue to develop products that work with your skin to correct the signs of aging. Questions? Addressing these issues without adversely affecting efficacy provides a breakthrough in opportunities with vitamin A in cosmetic formulations. The Ordinary Granactive Retinoid 2% in Squalane is a great contender for newbies, too, plus it's super affordable. The AHA Complex in Evening Detox is a trio of resurfacing Alpha Hydroxy Acids to deeply clean pores, help to banish breakouts and boost radiance. The Granactive Retinoid 2% in Squalane is a light-weight solution and absorbs into the skin efficiently, allowing for multiple serums to be applied in your regimen. [misc] Anyone have visible results with TO granactive retinoid? Retinoids don’t take as much time to reach that final product, so they’re more intense than retinol. I’ve been seeing a lot of people say that it’s impossible to see results from retinoids (vitamin A derivatives used in skincare, like retinol, tretinoin, adapalene, tazarotene) for a certain amount of time. This will deliver serious results with little to no irritation. Instead in recent years, milder synthetic and natural derivatives have become popular alternatives to Retinoic acid. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. As we age our skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Granactive Retinoid offers formulators the ability to harness the powerful anti-aging properties of retinoid without irritation and stability issues traditionally associated with older generations of vitamin A analogues. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of ageing than retinol without any of the irritation and drawbacks common with retinol. Higher levels are possible without irritation, depending on the formula. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. The ingredient can be incorporated into a wide variety of formulations and perfectly fits the global trend towards milder products. Granactive Retinoid shows up to 10x more stability than retinol in DMI especially when comparing the 50% residual content. Welcome Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. Gia Mazur is a staff writer for the Lifestyles Department of The Times-Tribune. Granactive Retinoid 5% in Squalane is a water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of ageing than retinol without any of the irritation and drawbacks common with retinol. Like the above, the Granactive Retinoid 5% in Squalane ($14) is a higher concentration of the lightweight Granactive retinoid. The 10% refers to the complex, which is granactive retinoid + the solvent dimethyl isosorbide in a 1:9 solution. Like all retinoids, the highly specific set of conjugated double bonds are susceptible to oxidation resulting in degradation. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. and were stored in low actinic glass bottles under a blanket of nitrogen gas. Results So Far : I am thrilled with the results from this Retinol. Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. 1. Granactive Retinoid helps renew skin plumpness, elasticity, and hydration to provide a radiant and fresh appearance. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. However, the novel retinoid was found to have 10 times better oxidative stability than retinol in DMI in thermal stress testing (see Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide). It is a delivery system for the active ingredient hydroxypinacolone retinoate (HPR), which is a retinoic acid ester. Granactive Retinoid is Hydroxypinacolone Retinoate, a cosmetic grade ester of all-trans retinoic acid. Reference 1. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. These results add credence to the beneficial safety and irritation profile of Granactive Retinoid as a topical cosmetic. … Privacy Policy Legal Terms To minimize the effects due to light and air oxidation, the products were stored in low actinic glassware and under nitrogen atmosphere. Due to its superior irritation and stability profile, Granactive Retinoid allows new and exciting opportunities with vitamin A, one of the most trusted efficacious anti-aging active ingredients. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit the skin complexion are switched on. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. The Ordinary Granactive Retinoid 2% In Squalane, 30 Milliliters 4.4 out of 5 stars 482 CDN$ 79.55 CDN$ 79 . ‘Granactive Retinoid’ is a next-generation retinoid active technology, which can not only achieve better anti-ageing results than traditional retinol but do so without the irritation commonly associated with it (it often causes redness and flaking). The novel retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. © 2020 Allured Business Media. This skin care active ingredient belongs to a class of chemical compounds called retinoids, which are natural and synthetic derivatives of vitamin A, capable of binding to retinoid receptors. Both compounds show signs of decomposition by being stored under atypical conditions. After a month, I’m already seeing a bigger difference in results than I had with the Granactive Retinoids or HPR Oils. The novel retinoid is intended to support anti-aging and anti-acne beauty treatments by providing low irritating, effective active delivery in daily maintenance applications. Additionally, OTC retinols are often combined with other ingredients, such as moisturizing ingredients, to minimize dryness/irritation, add antioxidants, or brighten the skin. The Ordinary Granactive Retinoid 5% in Squalane, 1 oz (or 30 mil as the rest of the world says) for $13.90. Full ingredients list Irritation profile was taken after application on a 24-hour occlusive patch test. Acne-prone skin may experience a temporary increase in acne during the first few weeks of using any form of retinoid including those used in this formulation. The novel retinoid is available as a concentrated and easily formulated anhydrous matrix containing 10% of the retinoid active in a premium delivery solvent. BIOLOGICAL PATHWAYS TO YOUTHFUL SKIN WITH GRANACTIVE RETINOID. Test samples were 0.5% retinoid in Granactive DMI (INCI: Dimethyl Isosorbide). This time varies: some people say 2 months, or 3 months, or 6 months. But not only is it less irritating than tretinoin, it is also less irritating than even 0.5 percent retinol. It is listed as an approved existing ingredient on China’s 2014 IECIC list. Ingredients are the star of this not-so-ordinary show so you … What it’s in: The Ordinary Granactive Retinoid 2% Emulsion. Irritation profile with a. Granactive Retinoid vs b. retinol, Thermal stress stability testing of Granactive Retinoid vs. Retinol in dimethyl isosorbide, Table 1. Reduction of lines and wrinkles after 14-day Granactive Retinoid application, Figure 2. What exactly is Granactive Retinoid? Moreover, Granactive Retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Reduction in pore size is observed, leading to an overall increase in skin clarity. Miscellaneous. An aliquot was removed at specified times and tested by high performance liquid chromatography (HPLC). So 10% really means 1% granactive retinoid. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly … Subscribe, Visit the website Squalane also has the added benefit of being an exceptional hydrator. It is recommended to formulate the novel retinoid in a manner that avoids infusing air/oxygen into the final cosmetic product. hydroxypinacolone retinoate in dimethyl isosorbide (DMI). When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion are switched on. Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) 2. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). This is an ideal progression from the above 2 percent option if you want to take it up a notch. Allured Business Media, 336 Gundersen Drive, Suite A, Carol Stream, IL, 60188 USA, Figure 1. The Ordinary Retinol 0.2% in Squalane - 30ml, Reduce The Appearances of fine Lines, of Photo Damage and of General Skin ageing 4.4 out of 5 stars 636 £8.98£8.98 (£29.93/100 ml) £9.13£9.13 Get it … Discussion/Conclusion: Retinoid compounds are known to be susceptible to decomposition by light and air oxidation. Allured Business Media utilizes Omeda to collect information on its behalf. First let’s talk about the 10% Granactive Retinoid claim. 55 Sérum Facial Antiedad - Retinol 0.5% in Squalane - 30 ml - The Ordinary 4.4 out of 5 stars 1,436 Retinoic acid is a topically applied ingredient recognized for its anti-aging benefits, however it can be irritating to skin and is sold as a prescription medication. You may want to try the Granactive Retinoid in Squalan or Retinol in Squalan when you place your next TO order. Contact us at: customerservice@cosmeticsandtoiletries.com The Ordinary Granactive Retinoid; Overall Rating: Texture/Feel: Thin, watery texture: Application: Super easy to apply with the dropper: Drying Time: Dries in about 10 seconds: Smell: Virtually no smell: Short Term Results: Hydrated and soft skin: Long Term Results: Helps reduce the appearance of fine lines: Ingredients: Caprylic is used to help the skin retain moisture. Log out So your skin prefers retinoids to acids, that's an important discovery! These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. The textures aren't great, that's true, but you can easily mix them. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE. Granactive Retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid. The Ordinary’s Granactive Retinoid 2% Emulsion is a gentle but hardworking product that targets all signs of aging and textural irregularities. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. Our science is complex, but the results are simple. Note: Prepared by Ronald V. Lerum, PhD, on Dec. 13, 2014. This is achieved because retinoids increase the rate of skin turnover, while also reducing the rate of collagen breakdown, leading to plumper, younger looking skin. The next-generation anti-aging formula with 2% Granactive Retinoid is dermatologically tested to offer less irritation & multi-fold better effect than other retinol and retinoid derivatives Boosts cell turnover & stimulates collagen production to erase fine lines and wrinkles, revealing radiant glowy skin This skin care active ingredient belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of Vitamin A capable of binding to retinoid receptors. Since HPR binds directly to retinoid receptors, its activity is similar to pure retinoic acid. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. All rights reserved. Applications include (but are not limited to) skin care, color cosmetic and body care formulations. Retinol (vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. It is apparent from the HPLC data that under similar conditions that the retinol is highly unstable. To “unsubscribe,” click the link at the bottom of any e-mail we send. The two primary reasons the use of retinoids is not universal are issues surrounding irritation potential and stability. S Mukherjee, A Date and V Patravale, Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety, Clin Interv Aging 1(4) 327-48 (2006). Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. Experiment: Both samples were subjected to thermal stress stability testing. HPR is a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid; Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. These derivatives are metabolized to the active form by skin cells. 1-201-791-6700. Retinol (Vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. The retinoid compounds were subjected to accelerated degradation by thermal stress testing. CHALLENGES WITH OLDER GENERATION VITAMIN A CHEMISTRIES. Dark spots and skin imperfections are reduced for a more even skin tone as a result of the retinoid’s promotion of skin cell-sloughing and a slowing effect on melanin production, which gives a brighter and more luminous appearance to skin. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. In recent years, milder synthetic and natural derivatives have become popular alternatives to retinoic acid. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE The mechanism of action of Granactive Retinoid is advanced compared to retinol derivatives. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. The Ordinary Granactive Retinoid 2% Emulsion The Ordinary THE ORDINARY A game changer from day one, The Ordinary is the stripped back premium skin care brand without the eye-watering price tag. As with all retinoids, this product should only be applied at night and used in conjunction with sunscreen to prevent extra … Granactive Retinoid (INCI Name: Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate), is a cosmetic grade ester of all-trans retinoic acid. Granactive Retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. The novel retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid (see Figure 2 and Table 1). Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. Retinoic acid, also known as tretinoin or Retin-A, is the active form of vitamin A, which binds directly to the skin cells' retinoid receptors. Finally, our night-time My Wrinkles booster is formulated with Granactive Retinoid to firm, plus, Hyaluronic Acid to plump and help boost a youthful complexion. This item is available at Beautylish. I've been using it nightly for 4 months now and honestly I can't say I really see a difference. The mechanism of action of the novel retinoid is advanced compared to retinol derivatives. This retinoid seemed the most appealing to me from their range of retinoids. The samples were placed in a heated water bath at 50°C and shaken. Our patients’ results speak for themselves.